Clinical Trials
Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standardized extract of Centella asiatica
Neelesh Kumar Nema 1, Niladri Maity, Birendra Kumar Sarkar, Pulok Kumar Mukherjee
Context: Centella asiatica (L.) Urban (Apiaceae), a valuable herb described in Ayurveda, is used in the indigenous system of medicine as a tonic to treat skin diseases.
TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. A status paper
G Belcaro 1, F-X Maquart, M Scoccianti, M Dugall, M Hosoi, M R Cesarone, R Luzzi, U Cornelli, A Ledda, B Feragalli
Plant-derived elements used for pharmacological applications constitute an increasing research field. Centella asiatica is widely used mainly as an extract (TECA). Triterpenic fractions, the primary constituents of Centella asiatica, produce a wide range of preventive and therapeutic effects. The modulation of collagen production and deposition in wound healing is of primary importance. TECA is also used to treat several microcirculatory problems, inflammatory skin conditions (leprosy, lupus, varicose ulcers, eczema, atopic dermatitis, psoriasis) and also intestinal problems, fever, amenorrhea and genitourinary conditions. Cognitive functions, anxiety and mental impairment may be also affected by TECA administration. New applications in neurology include nerve growth factor enhancement and applications in neurological degenerative conditions. Interaction with other products is also indicated in this document.
Topical management of striae distensae (stretch marks): prevention and therapy of striae rubrae and albae
S Ud-Din 1 2, D McGeorge 3, A Bayat 1 2
Striae distensae (SD) are common dermal lesions, with significant physical and psychological impact. Many therapeutic modalities are available but none can completely eradicate SD. The most common therapy is the application of topicals used both therapeutically and prophylactically. Even though there are many commercially available topical products, not all have sufficient level of evidence to support their continued use in SD.
The Natural Centella asiatica Extract Acts as a Stretch Marks Eraser: A Biological Evaluation
Cloé Boira *, Marie Meunier, Marine Bracq, Amandine Scandolera and Romain Reynaud
Stretch marks are far from being exclusively appearing on pregnant women and appear whenever the body experience a rapid growth. Into the dermis, collagen fibres are altered associated with a loss of orientation and the elastic network is disrupted leading to a fibrotic organisation. This results to epidermal tearing which produce skin lesions. Centella asiatica is a well-known medicinal plants rich in triterpenic actives molecules and traditionally used to treat wounds and help skin repair. The aim of this study was to evaluate Centella asiatica extract as a natural way to solve stretch marks concern and understand its mechanism of action. We have first evaluated the fibroblast’s proliferation based on scratch assay model and their genes expression by RT-qPCR. At the ex vivo level, elastin fibres were quantified by immunofluorescence.